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These passives are related to life, but don't fit into any other category.
These passives are related to life, but don't fit into any other category.


{| class="wikitable" style="width: 800px; text-align: center;"
{{passive table header}}
! style="width: 118px;" | Icon
{{:Bloodless|view=row}}
! Name
{{:Blood Magic|view=row}}
! Bonuses
{{:Pain Attunement|view=row}}
|-
{{:Chaos Inoculation|view=row}}
| [[Image:Passive-bloodless.png]]
| Bloodless
|
* Enemies cannot Leech [[Life]] from you
|-
| [[Image:Passive-keystone-bloodmagic.png]]
| [[Blood Magic]]
|
* Removes all [[Mana]]
* Spend [[Life]] instead of [[Mana]] for [[Skills]]
|-
| [[Image:Passive-keystone-painattunement.png]]
| [[Pain Attunement]]
|
* 30% more [[Damage Types#Spell Damage|Spell Damage]] when on [[Low Life]]
|-
| [[Image:Passive-keystone-chaosinoculation.png]]
| [[Chaos Inoculation]]
|
* Maximum [[Life]] becomes 1
* Immune to [[Damage Types#Chaos Damage|Chaos Damage]]
|}
|}
[[Category:Game mechanics]]

Revision as of 17:53, 24 June 2013

Life is shown in the lower left of the screen. You can use Flasks to restore it, or invest in passives that give you increased life regeneration, or leech.

Every class starts out with 50 Life, and gains +6 per level giving a base life of 644 at level 100. Strength increases Life, with every +10 node giving +5 Life. Characters do not begin with any life regeneration, but it is available from gear and passive skills.

   Maximum Life = (44 + (Level * 6) + (Strength / 2) + "to maximum Life") * (100% + "increased maximum Life")

In the above Strength, "to maximum Life" and "increased maximum Life" can come from equipment and passives.

Passives

There are passive skill nodes that grant additional life or a combination of bonuses including life. Other passives such as Life Regeneration and Life Leech are related to life, but do not increase maximum life.

The Chaos Inoculation Keystone will reduce your Life to one, nullifying any low-life spell damage bonuses, as well as any increased life or life regen passives taken. Pain Attunement will increase your spell damage if your Life is at or below 35% (this can be achieved through Blood Magic and reserves). Blood Magic removes your Mana, letting you use your Life to cast spells.

Please see the Minions page for information on Minion Life and the passives associated with them. Passives also exist which will increase the amount of Life regained from Flasks, as seen here.

Life

These passives either add a set amount to a character's maximum life or increase maximum life by a percentage.

Template:Passive table header

Life
Passive Skill
(2-4)% increased maximum Life [1]
10% increased maximum Life [1] [2]
4% increased maximum Life [1]
5% increased maximum Life [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15]
6% increased maximum Life [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13]

Life is a small passive skill. Most variants grant increased maximum life. One variant grants additional base maximum life.

Version history

Version Changes
1.3.0
  • The Templar, Marauder, and Duelist starting areas have been reworked significantly.
  • Added another life passive to the Thick Skin cluster, but reduced life bonuses by 1%, taking the total life on the cluster from 20% up to 22%.
1.2.0
  • Percentage-based life increases have been reduced slightly and redistributed more evenly through the tree.
0.11.0
  • Life percentage passives and most Energy Shield percentage passives have been reduced in line with the changes to monster damage.

ru:Здоровье (пассивное умение)

Thick Skin
Notable Passive Skill
10% increased maximum Life
8% chance to Avoid Elemental Ailments [1]

Thick Skin is a notable passive skill that grants increased maximum life. It also grants additional chance to avoid being chilled, frozen, shocked or ignited.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Violet OilSilver OilSilver OilThick Skin
10% increased maximum Life
8% chance to Avoid Elemental Ailments

Version history

Version Changes
1.2.0
  • Thick Skin also grants chance to avoid elemental status ailments.
  • Percentage-based life increases have been reduced slightly and redistributed more evenly through the tree.
1.0.0
  • Most percentage based life passives have been increased by 2%. Several life passives have been removed from the tree or integrated into nearby nodes.
0.11.0
  • Life percentage passives and most Energy Shield percentage passives have been reduced in line with the changes to monster damage.
Purity of Flesh
Notable Passive Skill
10% increased maximum Life
+8% to Chaos Resistance
8% increased maximum Energy Shield [1]

Purity of Flesh is a notable passive skill that grants increased maximum life and increased maximum energy shield. It also grants additional chaos resistance.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Clear OilBlack OilSilver OilPurity of Flesh
10% increased maximum Life
+8% to Chaos Resistance
8% increased maximum Energy Shield

Version history

Version Changes
3.16.0
  • Now grants 8% increased maximum Energy Shield. [Undocumented This change was not documented by any official sources. It was discovered through player testing or datamining.]


3.11.0
  • [Undocumented This change was not documented by any official sources. It was discovered through player testing or datamining.][1]
    • Now grants 10% increased maximum Life (up from 8%).
    • No longer grants +10 to Strength.


3.8.0


1.2.0
  • Purity of Flesh also grants strength.
  • Percentage-based life increases have been reduced slightly and redistributed more evenly through the tree.


1.0.0
  • Divine Toughness renamed to Purity of Flesh.
  • Small chaos resistance nodes have been removed or integrated into nearby passives.
  • Most percentage based life passives have been increased by 2%.


0.11.0
  • Life percentage passives and most Energy Shield percentage passives have been reduced in line with the changes to monster damage.
Unknown
  • Introduced to the game.

References

  1. Bex_GGG (June 17, 2020). "All Notables and Keystones in Path of Exile: Harvest". Official Path of Exile forums. Retrieved June 18, 2020.
Discipline and Training
Notable Passive Skill
+30 to maximum Life
10% increased maximum Life [1]

Discipline and Training is a notable passive skill that grants additional base maximum life. It also grants increased maximum life.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Black OilSilver OilSilver OilDiscipline and Training
+30 to maximum Life
10% increased maximum Life

Version history

Version Changes
0.11.0
  • Life percentage passives and most Energy Shield percentage passives have been reduced in line with the changes to monster damage.

Fitness Gymnastics

Written in Blood
Notable Passive Skill
10% increased maximum Life
10% increased maximum Energy Shield
+10 to Strength [1]

Written in Blood is a notable passive skill that grants increased maximum life and increased maximum energy shield. It also grants additional strength.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Sepia OilViolet OilGolden OilWritten in Blood
10% increased maximum Life
10% increased maximum Energy Shield
+10 to Strength

Version history

Version Changes
3.16.0
  • Now grants 10% increased maximum Life (up from 8%). [Undocumented This change was not documented by any official sources. It was discovered through player testing or datamining.]
1.2.0
  • Written in Blood grants energy shield.
  • The area surrounding the Witch, Shadow and Ranger has been redesigned.
  • There are now two Life and Energy Shield clusters.
1.0.0
  • Several Notable Passives have been renamed.
0.11.0
  • Notable passives with non-unique names have been renamed to their own names.
  • Life percentage passives and most Energy Shield percentage passives have been reduced in line with the changes to monster damage.
Blood Siphon
Notable Passive Skill
10% increased maximum Life
+20 to Strength
Gain 10 Life per Enemy Killed [1]

Blood Siphon is a notable passive skill that grants increased maximum life. It also grants additional strength and life gain on kill.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Azure OilOpalescent OilSilver OilBlood Siphon
10% increased maximum Life
+20 to Strength
Gain 10 Life per Enemy Killed

Version history

Version Changes
3.11.0
  • Life gained on Kill is now +10 (up from +5). [Undocumented This change was not documented by any official sources. It was discovered through player testing or datamining.]
1.2.0
  • Conditioning renamed to Blood Siphon.
  • The Witch and Shadow passive tree starting area has been redesigned. Many values have been adjusted.
1.0.0
  • Most percentage based life passives have been increased by 2%. Several life passives have been removed from the tree or integrated into nearby nodes.
0.11.0
  • Notable passives with non-unique names have been renamed to their own names.
  • Life percentage passives and most Energy Shield percentage passives have been reduced in line with the changes to monster damage.
Heart of the Warrior
Notable Passive Skill
+10 to Strength
+20 to maximum Life
10% increased maximum Life [1]

Heart of the Warrior is a notable passive skill that grants additional strength and base maximum life. It also grants increased maximum life.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Violet OilSilver OilGolden OilHeart of the Warrior
+10 to Strength
+20 to maximum Life
10% increased maximum Life

Version history

Version Changes
1.3.0
  • Base maximum Life reduced from 30 to 20.
  • Increased maximum Life added.
1.1.0
  • The Marauder starting area has been reworked substantially.
  • Renamed Heart of Gladiator the to Heart of the Warrior.
0.11.0
  • The Strength bonus of Heart of the Gladiator has been reduced to +10.

|}

Life Regeneration

By default, characters do not regenerate life. These passives increase life regeneration as a percentage of maximum life per second.

Icon Name Bonuses
File:Passive-liferegeneration.png Life Regeneration
  • 0.4% of Life Regenerated per second

  • 1.0% of Life Regenerated per second
File:Passive-trollsblood.png Troll's Blood
  • 1.5% of Life Regenerated per second
File:Passive-golemsblood.png Golem's Blood
  • 1.5% of Life Regenerated per second
File:Passive-endurancechargesmall.png Life Regeneration per Endurance Charge

Life Leech

These passives add life leech to attacks as a percentage of physical damage dealt.

The regeneration rate of life gained from life leech is a set rate equal to 20% of maximum life per second. If you have 1000 maximum life, and leech 600 life with a single attack, it will take three seconds for that life to be applied to your current life; if you leech 100 life with a single attack, it will take half a second. You earn the full amount of life leeched upon dealing damage, it is only the rate (as a function of your maximum life) that determines how long it takes to be applied to your current life - if you leech a large amount of life during a battle, you may find that the regeneration continues long after the battle is over. The Vaal Pact Keystone will allow life leech to apply immediately at the cost of life recovery from flasks and regeneration having no effect.

Similar to flasks, the regeneration from leech will stop if you reach maximum life.

Icon Name Bonuses
File:Passive-lifeleech.png Life Leech
File:Passive-blooddrinker.png Blood Drinker
File:Passive-soulraker.png Soul Raker
File:Passive-soulraker.png Essence Raker
File:Passive-soulraker.png Spirit Raker

Life Gain on Hit

These passives add a set amount of life gain on hit to attacks.

When an enemy is hit by your attack, you gain an amount of life equal to combined life gain on hit bonuses from passives and all other sources. This applies to each enemy hit by your attacks, so a single attack that hits multiple targets can trigger more than one life gain on hit effect. Unlike life leech, life gained this way is restored instantly.

Icon Name Bonuses
File:Passive-lifeleech.png Life Gain on Hit
  • 2 Life gained for each enemy hit by your attacks

Life Gain on Killing Blow

These passives add a set amount of life gain on killing blow to attacks.

When an enemy is killed by your attack, you gain an amount of life equal to combined life gain on killing blow bonuses from passives and all other sources. This effect triggers once for each enemy killed. Unlike life leech, life gained this way is restored instantly.

Icon Name Bonuses
File:Passive-lifeleech.png Life Gain on Killing Blow
  • 10 Life gained when you kill an enemy

Miscellany

These passives are related to life, but don't fit into any other category.

Template:Passive table header

Bloodless
Notable Passive Skill
Enemies Cannot Leech Life From you
10% increased maximum Life [1]

Bloodless is a notable passive skill that grants increased maximum life. It also prevents enemies from leeching life from the character.

Anointment

Blight anointment to unlock the passive:

Oil #1Oil #2Oil #3Outcome
Amber OilCrimson OilGolden OilBloodless
Enemies Cannot Leech Life From you
10% increased maximum Life

Version history

Version Changes
3.16.0
  • Now grants 10% increased maximum Life (up from 8%). [Undocumented This change was not documented by any official sources. It was discovered through player testing or datamining.]
1.3.0
  • Life reduced from 10% to 8%.
  • The Templar, Marauder, and Duelist starting areas have been reworked significantly.
Unknown
  • Bloodless also grants increased maximum life.

ru:Бескровный

For the support gem previously named Blood Magic Support, see Arrogance Support. For the other support gem with related effects, see Lifetap Support.
Blood Magic
Keystone
Removes all mana
10% more maximum Life
Skills Cost Life instead of Mana
Skills Reserve Life instead of Mana [1]
Lay open your veins, and draw power from your own spilled life.

Blood Magic (often referred to as BM) is a keystone passive skill that converts all mana cost and reservation to use life instead. It also gives you more maximum life and removes your mana.

Mechanics

Skills that reserve mana will reserve life and skills that cost mana will cost life instead. Mods that affect mana cost and mana reservation such as X% increased/reduced Mana Cost of Skills, + X to Total Mana Cost of Skills and X% increased/reduced Mana Reservation Efficiency of Skills have no effect on the life cost and life reservation of skills. It is not possible to commit suicide through Blood Magic.

If taken with Eldritch Battery, your energy shield will continue to protect mana but will not be spent.

While you have Blood Magic, you are neither at full mana nor low mana.[1]

Taking this keystone along with Sanguimancy from Warlock of the Mists will provide the 50% increased Life Reservation Efficiency of Skills stat, but otherwise impart no additional benefit.

Location

Blood Magic is located in the bottom left corner of the tree.

Class Distance from start
Marauder 12
Duelist 12
Templar 14
Scion 16
Ranger 19
Witch 21
Shadow 26

Related unique items

These unique items have the Blood Magic modifier, which provides the same effect as this keystone. Taking the keystone in addition to equipping one of these items will impart no additional benefit.

ItemBase ItemRequired levelStats
Skin of the LordsSkin of the Lords
Simple Robe
Movement Speed: -3%Item has no level requirement and Energy Shield (Hidden)
Sockets cannot be modified
+2 to Level of Socketed Gems
100% increased Global Defences
You can only Socket Corrupted Gems in this item
Item has 6 Sockets and is fully linked (Hidden)
<Random Keystone>
CorruptedThe Lords are chosen so carefully.
Only they may grace His flesh.
Simple Robe1Item has no level requirement and Energy Shield (Hidden)
Sockets cannot be modified
+2 to Level of Socketed Gems
100% increased Global Defences
You can only Socket Corrupted Gems in this item
Item has 6 Sockets and is fully linked (Hidden)
<Random Keystone>
Acrobatics
Ancestral Bond
Arrow Dancing
Avatar of Fire
Blood Magic
Call to Arms
Conduit
Crimson Dance
Divine Shield
Hex Master
Eldritch Battery
Elemental Equilibrium
Elemental Overload
Eternal Youth
Ghost Dance
Ghost Reaver
Glancing Blows
Iron Grip
Iron Reflexes
Iron Will
Lethe Shade
Magebane
Mind Over Matter
Minion Instability
Pain Attunement
Perfect Agony
Point Blank
Precise Technique
Resolute Technique
Runebinder
Imbalanced Guard
Solipsism
Supreme Ego
The Agnostic
The Impaler
Unwavering Stance
Vaal Pact
Versatile Combatant
Wicked Ward
Wind Dancer
Zealot's Oath
Corrupted
Malachai's SimulaMalachai's Simula
Iron Mask
Evasion: (48-60)
Energy Shield: (11-14)
Requires Level 17, 21 Dex, 21 Int+20 to Strength
+(20-30)% to Lightning Resistance
Spells have a 20% chance to deal Double Damage
Blood Magic
It was a sliver of Malachai's soul
that animated the first Eternal Guardian.
Iron Mask17+20 to Strength
+(20-30)% to Lightning Resistance
Spells have a 20% chance to deal Double Damage
Blood Magic
Replica Tukohama's FortressReplica Tukohama's Fortress
Ebony Tower Shield
Chance to Block: 25%
Armour: (357-411)
Movement Speed: -3%
Requires Level 61, 159 Str+(20-30) to maximum Life+(80-100) to maximum Life
You can Cast an additional Brand
20% increased Critical Strike Chance per Brand
40% increased Brand Damage
Blood Magic
"As one of our few creations that did not cost any fatalities,
Prototype #10 bore unexpectedly positive results."
Ebony Tower Shield61+(20-30) to maximum Life+(80-100) to maximum Life
You can Cast an additional Brand
20% increased Critical Strike Chance per Brand
40% increased Brand Damage
Blood Magic
Tukohama's FortressTukohama's Fortress
Ebony Tower Shield
Chance to Block: 25%
Armour: (357-411)
Movement Speed: -3%
Requires Level 61, 159 Str+(20-30) to maximum Life40% increased Totem Damage
+(80-100) to maximum Life
+1 to maximum number of Summoned Totems
+300 Armour per Summoned Totem
Blood Magic
Tukohama knew that he could not lose a fight in his fortress.
So he carried his fortress to the fight.
Ebony Tower Shield61+(20-30) to maximum Life40% increased Totem Damage
+(80-100) to maximum Life
+1 to maximum number of Summoned Totems
+300 Armour per Summoned Totem
Blood Magic

Version history

Version Changes
3.17.0
  • Now grants 10% more maximum Life.
  • No longer grants Spend Life instead of Mana for effects of Skills.
3.14.0
  • The mod Socketed gems have Blood Magic has been removed from the game and replaced by Socketed Gems Cost and Reserve Life instead of Mana, or Socketed Gems Reserve Life instead of Mana, or Socketed Gems Cost Life instead of Mana, affects all version. [Undocumented This change was not documented by any official sources. It was discovered through player testing or datamining.]
2.1.1
  • Fixed a bug where you could not get stunned while wearing the SkyforthSkyforth
    Sorcerer Boots
    Energy Shield: (51-59)Requires Level 67, 123 Int+(60-120) to maximum Mana
    30% increased Movement Speed
    25% chance to gain a Power Charge on Critical Strike
    12% increased Reservation Efficiency of Skills
    You have no Life Regeneration
    Stun Threshold is based on 500% of your Mana instead of Life
    The quick die young, the brilliant go mad,
    and the powerful stand alone in a wasteland of their own creation.
    boots with the Blood Magic Keystone allocated.
1.3.0
  • When Blood Magic is active, your mana orb no longer shows as fully reserved.
1.0.0
  • Players now cannot spend or reserve their last point of life with Blood Magic.
0.9.12p
  • Fixed a bug where skills would appear disabled if you have Blood Magic.
0.9.12m
  • Fixed a bug where players who cast their auras and then return to town to select the Blood Magic keystone passive will have free auras until they log out.
0.9.11
  • Totems with Blood Magic (from either a Support Gem or the player's passives) now do not spend their own life to cast spells.
0.9.10
  • Totems using percentage reserve skills with blood magic now correctly base the cost as a percentage of their life rather than yours.
0.9.9c
  • Blood Magic now no longer prevents traps from working.
0.9.7d
  • Fixed the interaction between Chaos Inoculation and Blood Magic so that there's no crazy bugged death state any more. If you try to reserve life or mana when you have both of these keystones, you will now die properly.
0.9.4
  • Introduced to the game.

References

  1. Mark_GGG (November 15, 2013). "Infernal Mantle and Blood Magic". Official Path of Exile Forums. Retrieved May 25, 2021.
Pain Attunement
Keystone
30% more Spell Damage when on Low Life [1]
Embrace the pain, drink it in. Your enemies will know your agony tenfold.

Pain Attunement is a keystone passive skill that grants more spell damage when the character is on low life.

Location

Pain Attunement is a standalone keystone located on the inner layer of the transition area between Witch and Shadow.

Class Distance from start
Shadow 7
Witch 7
Scion 11
Templar 16
Ranger 17
Duelist 21
Marauder 21

Interactions

The low life threshold can be met using Petrified BloodPetrified BloodSpell
Level: (1-20)
Reservation: 35% Mana
Cooldown Time: 1.00 sec
Can Store 1 Use(s)
Cast Time: Instant
Requires Level 24Applies a buff that protects the lower half of your life, preventing some of the immediate life loss when damaged by hits and applying the loss over time instead. Your life cannot be raised above low life other than by flasks, and while above low life, skills will cost life as well as mana.Life Recovery other than Flasks cannot Recover Life to above Low Life
When taking Damage from Hits, 40% of Life loss below half Life is Prevented, then (100-81)% of Life loss prevented this way is lost over 4 seconds
Skills gain a Base Life Cost equal to 40% of Base Mana Cost while not on Low Life

Additional Effects From 1-20% Quality:
-(0.25-5)% of Life loss prevented is lost over 4 seconds
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
, reserving life via Arrogance SupportArrogance SupportAura, Support
Icon: B
Level: (1-20)
Cost & Reservation Multiplier: (220-201)%
Requires Level 31Supports any non-blessing skill with a reservation.Supported Skills have (10-19)% increased Aura effect
Supported Skills Reserve Life instead of Mana

Additional Effects From 1-20% Quality:
Supported Skills have (0.25-5)% increased Aura effect
This is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Skill Gem you wish to augment. Right click to remove from a socket.
, or equipping a Coward's LegacyCoward's Legacy
Chain Belt
Requires Level 52+(9-20) to maximum Energy Shield+(15-20) to all Attributes
(5-10)% increased Movement Speed
50% increased Effect of Curses on you
You count as on Low Life while you are Cursed with Vulnerability
You are Cursed with Vulnerability
Death is your most important duty.
Face it, or curse your bloodline for all eternity.
.

If doing the above, your Light radius will be dramatically reduced. You can counteract this using the Energy Shield Mastery that grants Light Radius is based on Energy Shield instead of Life.

Related unique items

ItemBase ItemRequired levelStats
Crown of ThornsCrown of Thorns
Vine Circlet
Energy Shield: (157-235)+(150-225) to maximum Energy Shield
Reflects 5 Physical Damage to Melee Attackers
+25 Physical Damage taken from Attack Hits
Pain Attunement
Lift it lightly, don it slow.
The spikes point out and in, you know.
Vine Circlet1+(150-225) to maximum Energy Shield
Reflects 5 Physical Damage to Melee Attackers
+25 Physical Damage taken from Attack Hits
Pain Attunement
Skin of the LordsSkin of the Lords
Simple Robe
Movement Speed: -3%Item has no level requirement and Energy Shield (Hidden)
Sockets cannot be modified
+2 to Level of Socketed Gems
100% increased Global Defences
You can only Socket Corrupted Gems in this item
Item has 6 Sockets and is fully linked (Hidden)
<Random Keystone>
CorruptedThe Lords are chosen so carefully.
Only they may grace His flesh.
Simple Robe1Item has no level requirement and Energy Shield (Hidden)
Sockets cannot be modified
+2 to Level of Socketed Gems
100% increased Global Defences
You can only Socket Corrupted Gems in this item
Item has 6 Sockets and is fully linked (Hidden)
<Random Keystone>
Acrobatics
Ancestral Bond
Arrow Dancing
Avatar of Fire
Blood Magic
Call to Arms
Conduit
Crimson Dance
Divine Shield
Hex Master
Eldritch Battery
Elemental Equilibrium
Elemental Overload
Eternal Youth
Ghost Dance
Ghost Reaver
Glancing Blows
Iron Grip
Iron Reflexes
Iron Will
Lethe Shade
Magebane
Mind Over Matter
Minion Instability
Pain Attunement
Perfect Agony
Point Blank
Precise Technique
Resolute Technique
Runebinder
Imbalanced Guard
Solipsism
Supreme Ego
The Agnostic
The Impaler
Unwavering Stance
Vaal Pact
Versatile Combatant
Wicked Ward
Wind Dancer
Zealot's Oath
Corrupted

Version history

Version Changes
0.9.9
  • Increased damage bonus from 25% to 30%.
0.9.6
  • Introduced to the game.

ru:Вдохновение болью

Chaos Inoculation
Keystone
Maximum Life becomes 1, Immune to Chaos Damage [1]
Give up everything in pursuit of greatness - even life itself.

Chaos Inoculation (often referred to as CI) is a keystone passive skill that grants immunity to chaos damage, but sets maximum life to 1.

Although the character must survive entirely on energy shield instead of life, immunity to chaos damage can be a significant advantage.

Interactions

The chance and duration of both being stunned and receiving an elemental status ailments is based on your maximum life before CI takes effect[1]. Maximum Life modifiers such as increased maximum Life, reduced maximum Life, etc. apply to the life before CI is applied. Since this base life value is then overwritten by CI, the only advantage life modifiers provide to a CI character is the reduction on stun and status ailment thresholds.

Low life conditions will never take effect while CI is enabled. Effects such as Pain Attunement and On Low Life mods on gear will not activate. For these effects, you must have 50% or less of your current maximum life. Chaos Inoculation sets your maximum life to 1. The exception to this is if you have Coward's LegacyCoward's Legacy
Chain Belt
Requires Level 52+(9-20) to maximum Energy Shield+(15-20) to all Attributes
(5-10)% increased Movement Speed
50% increased Effect of Curses on you
You count as on Low Life while you are Cursed with Vulnerability
You are Cursed with Vulnerability
Death is your most important duty.
Face it, or curse your bloodline for all eternity.
equipped.

Full life conditions will always take effect because you are always at 100% of 1 life, making the condition of Damage on Full Life SupportDamage on Full Life SupportAttack, Support
Icon: f
Level: (1-20)
Cost & Reservation Multiplier: 130%
Requires Level 18Supports attack skills, providing a bonus to all damage dealt by those skills while your life is full.Supported Attack Skills deal (20-34)% more Damage while on Full Life

Additional Effects From 1-20% Quality:
Supported Skills deal (0.5-10)% increased Damage
This is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Skill Gem you wish to augment. Right click to remove from a socket.
easy to maintain.

Interaction with life reduction

Life reductions apply before CI which sets life to 1. For example from Ephemeral EdgeEphemeral Edge
Dusk Blade
One Handed Sword
Physical Damage: 19-54
Elemental Damage: 1-75
Critical Strike Chance: 5.00%
Attacks per Second: 1.30
Weapon Range: 1.1 metres
Requires Level 32, 57 Str, 57 Dex40% increased Global Accuracy Rating+10 to Intelligence
50% increased Global Critical Strike Chance
(40-50)% increased maximum Energy Shield
25% reduced maximum Life
Adds 1 to 75 Lightning Damage
Attacks with this Weapon have Added Maximum Lightning Damage equal to 20% of Player's Maximum Energy Shield
In the rift between future and past,
life passes quickly.
. Obtaining 100%+ reduced Maximum Life will not affect the 1 Life value.

Blood Magic

When linked with Lifetap SupportLifetap SupportSupport, Duration
Icon: T
Level: (1-20)
Cost & Reservation Multiplier: 300%
Requires Level 8Supports any non-blessing skill. Minions cannot gain the Lifetap buff.Supported Skills Cost Life instead of Mana
Gain Lifetap after Spending a total of (23-273) Life on Upfront
Costs and Effects of a Supported Skill
Supported Skills deal (10-19)% more Damage while you have Lifetap
Lifetap lasts 4 seconds

Additional Effects From 1-20% Quality:
Lifetap lasts +(0.1-2) seconds
This is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Skill Gem you wish to augment. Right click to remove from a socket.
or Arrogance SupportArrogance SupportAura, Support
Icon: B
Level: (1-20)
Cost & Reservation Multiplier: (220-201)%
Requires Level 31Supports any non-blessing skill with a reservation.Supported Skills have (10-19)% increased Aura effect
Supported Skills Reserve Life instead of Mana

Additional Effects From 1-20% Quality:
Supported Skills have (0.25-5)% increased Aura effect
This is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Skill Gem you wish to augment. Right click to remove from a socket.
, or while taking the Blood Magic Keystone or other similar effects, affected skills (including auras) cannot be cast, unless the skill has 0 Cost and/or Reservation. The mod Skills Cost no Mana or Life while Focussed thus allows CI builds to cast skills with Life Costs (e.g. ReapReapSpell, Physical, AoE, Duration
Level: (1-20)
Cost: (25-46) Life
Cast Time: 0.80 sec
Critical Strike Chance: 6.00%
Effectiveness of Added Damage: 210%
Requires Level 28A bloody scythe swipes across a selected area, applying a physical damage over time debuff and hitting enemies with physical damage. If any survive, you gain a blood charge which raises the damage and cost of the skill. Players can have 5 maximum blood charges.Deals (57-943) to (86-1414) Physical Damage
Deals (120.2-1463.3) Base Physical Damage per second
Base duration is 1.00 seconds
Modifiers to Spell Damage apply to this Skill's Damage Over Time effect
Gain a Blood Charge if this Skill Hits Enemies and none of them Die
Lose a Blood Charge when an Enemy Dies while affected by this Skill's Debuff
Costs 20% more Life per Blood Charge
Deals 15% more Damage per Blood Charge

Additional Effects From 1-20% Quality:
Deals +(0.25-5)% more Damage per Blood Charge
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
, Corrupting FeverCorrupting FeverSpell, Duration, Physical
Level: (1-20)
Cost: (78-520) Life
Cooldown Time: 1.00 sec
Can Store 1 Use(s)
Cast Time: Instant
Requires Level 16Draws out your own blood to power a buff for a duration, letting this skill inflict the Corrupting Blood debuff on enemies you hit, dealing physical damage over time for a short secondary duration. The buff's duration will be refreshed if you spend enough life before it expires.Deals (7.8-335.4) Base Physical Damage per second
Base duration is 6.00 seconds
Base secondary duration is 1.00 seconds
Buff Duration is refreshed after you spend a total of (26-205) Life

Additional Effects From 1-20% Quality:
(1-20)% increased Skill Effect Duration
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
or Blood RageBlood RageSpell, Duration, Physical
Level: (1-20)
Cost: (12-29) Life
Cooldown Time: 1.00 sec
Can Store 1 Use(s)
Cast Time: Instant
Requires Level 16Adds a buff that deals Physical Damage over time, while increasing Attack Speed and Life Leech. Killing an enemy while this buff is active refreshes the buff duration, and can grant a Frenzy Charge.Base duration is (7.00-10.80) seconds
Grants (5-15)% increased Attack Speed
1.2% of Attack Physical Damage Leeched as Life
You take 4% of your Maximum Life per second as Physical Damage
You take 4% of your Maximum Energy Shield per second as Physical Damage
25% chance to gain a Frenzy Charge on Kill

Additional Effects From 1-20% Quality:
Grants (0.25-5)% increased Attack Speed
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
).

Chaos resistance reduction/penetration

Since CI grants a flat-out immunity to chaos damage, effects that reduce or penetrate chaos resistance (i.e. Occultist's Void Beacon) have no effect against CI.[2]

Being Poisoned

Being Immune to Chaos Damage means that Chaos Damage cannot inflict poison (to the entity immune to chaos damage), although physical damage can still inflict poison.

CI builds

It is generally best to wait until you have high energy shield before taking CI because it's much easier to survive on life at lower levels. Don't be afraid to take life passive skills for survivability while leveling up, since you can remove them later.

Characters with CI are usually more susceptible to stun and status ailments because of their low base life. Rather than taking otherwise useless life nodes as described above, Stun can be mitigated by obtaining Stun Immunity (e.g Vile Bastion), stacking Chance to Avoid Stuns, or through niche items such as SkyforthSkyforth
Sorcerer Boots
Energy Shield: (51-59)Requires Level 67, 123 Int+(60-120) to maximum Mana
30% increased Movement Speed
25% chance to gain a Power Charge on Critical Strike
12% increased Reservation Efficiency of Skills
You have no Life Regeneration
Stun Threshold is based on 500% of your Mana instead of Life
The quick die young, the brilliant go mad,
and the powerful stand alone in a wasteland of their own creation.
or ValyriumValyrium
Moonstone Ring
Requires Level 38+(15-25) to maximum Energy Shield+(30-40) to maximum Energy Shield
+(30-40)% to Fire Resistance
-40% to Cold Resistance
Stun Threshold is based on Energy Shield instead of Life
They will rise and fall in fire and blood.
. Status ailments can be mitigated or avoided in a variety of different ways, including Pantheon Powers, Purity of ElementsPurity of ElementsAura, Spell, AoE
Level: (1-20)
Reservation: 50% Mana
Cooldown Time: 1.20 sec
Can Store 1 Use(s)
Cast Time: Instant
AoE Radius: 36
Requires Level 24Casts an aura that grants elemental resistances and elemental ailment immunity to you and your allies.+(0-1.9) metres to radius
You and nearby allies gain +(20-34)% to all Elemental Resistances
You and nearby allies are Immune to all Elemental Ailments

Additional Effects From 1-20% Quality:
You and nearby allies gain +(0.25-5)% to all Elemental Resistances
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
, Chance to Avoid Ailments, Reduced Effect/Duration of Ailments on You, or niche items such as AuxiumAuxium
Crystal Belt
Requires Level 79+(60-80) to maximum Energy Shield+(60-70) to maximum Energy Shield
+(45-55) to maximum Mana
Chill Effect and Freeze Duration on you are based on 100% of Energy Shield
(20-25)% increased Elemental Damage with Attack Skills per Power Charge
0.2% of Attack Damage Leeched as Mana per Power Charge
As long as the soul is unfettered, so is the body.
.

Chaos Inoculation works well with some other keystone passives, such as:

  • Ghost Reaver converts sources of life leech into energy shield leech, at the cost of disabling ES recharge.
  • Zealot's Oath applies life regeneration to energy shield. The amount recovered is based on the same % of your max ES, rather than your max life. Flat regeneration recovers the same amount. Note that "regeneration" does not include life flasks, as they are just "Recovery".
  • Divine Shield can provide a large amount of regeneration to builds that also stack large amounts of Armour and Physical Damage Reduction.
  • Ghost Dance can instantly recover ES on builds that have a decent amount of Evasion, at the cost of capping your energy shield by your evasion rating.
  • Wicked Ward can be used by builds relying on recharge, sacrificing some recharge rate for uninterruptible recharge.

Location

Chaos Inoculation is located on the northeast edge of the skill tree.

Class Distance from start
Witch 9
Shadow 11
Scion 14
Templar 16
Ranger 19
Marauder 23
Duelist 25

Related unique items

ItemBase ItemRequired levelStats
Midnight BargainMidnight Bargain
Engraved Wand
Wand
Physical Damage: 21-38
Critical Strike Chance: 7.00%
Attacks per Second: 1.50
Requires Level 40, 131 Int(22-26)% increased Spell Damage+(10-20) to Intelligence
Minions have (20-30)% increased Movement Speed
Minions deal (50-70)% increased Damage
+1 to maximum number of Raised Zombies
+1 to maximum number of Skeletons
+1 to maximum number of Spectres
Reserves 30% of Life
Cannot be used with Chaos Inoculation
A chilling hush, a scraping sound
Of things no more entombed in ground.
A shambling horde is on its way
To crush the very light of day.
Engraved Wand40(22-26)% increased Spell Damage+(10-20) to Intelligence
Minions have (20-30)% increased Movement Speed
Minions deal (50-70)% increased Damage
+1 to maximum number of Raised Zombies
+1 to maximum number of Skeletons
+1 to maximum number of Spectres
Reserves 30% of Life
Cannot be used with Chaos Inoculation
Replica Midnight BargainReplica Midnight Bargain
Engraved Wand
Wand
Physical Damage: 21-38
Critical Strike Chance: 7.00%
Attacks per Second: 1.50
Requires Level 40, 131 Int(22-26)% increased Spell Damage+(10-20) to Intelligence
Minions have (40-50)% increased Movement Speed
Minions deal (50-70)% increased Damage
+6 to maximum number of Raging Spirits
+3 to maximum number of Summoned Phantasms
Reserves 30% of Life
Cannot be used with Chaos Inoculation
"Simply incredible. I caught an escaping test subject myself with swarms of burning skulls. Delightful!"
- Researcher Olesya
Engraved Wand40(22-26)% increased Spell Damage+(10-20) to Intelligence
Minions have (40-50)% increased Movement Speed
Minions deal (50-70)% increased Damage
+6 to maximum number of Raging Spirits
+3 to maximum number of Summoned Phantasms
Reserves 30% of Life
Cannot be used with Chaos Inoculation

Version history

Version Changes
3.14.1
  • The in-game Character Screen now displays "Immune to Chaos Damage" if you have the Chaos Inoculation keystone passive skill allocated.
3.14.0
  • Now does not change the displayed chaos resistance to 100%.[3]
3.0.0
  • Vaal Pact now only applies to leeched life.
  • The passive skills behind Chaos Inoculation have been removed.
2.3.2
  • Fixed an issue where players' life totals could get out of sync when they died from degeneration damage with Chaos Inoculation allocated.
0.10.0
  • Chaos Inoculation now grants no additional energy shield bonus. Its complete immunity to chaos damage, synergy with Blood Rage and other skill combos are deemed sufficient upside to counteract the life penalty.
0.9.10e
  • The Chaos Inoculation keystone passive skill now grants +50% Energy Shield rather than +80%.
0.9.7d
  • Fixed the interaction between Chaos Inoculation and Blood Magic so that there's no crazy bugged death state any more. If you try to reserve life or mana when you have both of these keystones, you will now die properly.
0.9.6
  • Changed the Chaos Inoculation keystone so that your "real" life value is still used for checks related to stun and elemental status ailments. This will mean that you don't receive giant stuns/chills due to being reduced to 1 life.
0.9.5h
  • Chaos Inoculation now grants a multiplicative increase to Energy Shield.
0.9.5
  • Chaos Inoculation now grants +80% energy shield rather than +20%
0.9.4
  • Added 12 Keystone Passives.
  • Chaos Inoculation: 20% increased maximum energy shield. Provides immunity to chaos damage. Maximum life becomes 1.

References

  1. https://fr.pathofexile.com/forum/view-thread/18201/page/1
  2. Dan_GGG (February 11, 2016). "Chaos Penetration vs CI?". Official Path of Exile Forums. Retrieved February 11, 2016.
  3. Mark_GGG (April 17, 2021). "re: CI (Chaos Inoculation) not granting 100% chaos immunity as it's supposed to with this patch". Official Path of Exile Forums. Retrieved April 20, 2021.

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