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Chaos Inoculation
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Chaos Inoculation (often referred to as CI) is a keystone passive skill that grants immunity to chaos damage, but sets maximum life to 1.
Although the character must survive entirely on energy shield instead of life, immunity to chaos damage can be a significant advantage.
Interactions
The chance and duration of both being stunned and receiving an elemental status ailments is based on your base life before CI takes effect. Maximum Life modifiers such as increased maximum Life, reduced maximum Life, etc. apply to the life before CI is applied. Since this base life value is then overwritten by CI, the only advantage life modifiers provide to a CI character is the reduction on stun and status ailment.
Chaos Inoculation no longer grants immunity degeneration effect of 
Blood RageBlood RageSpell, Duration, Physical
Level: (1-20)
Cost: (12-29) Life
Cooldown Time: 1.00 sec
Can Store 1 Use(s)
Cast Time: InstantRequires Level 16Adds a buff that deals Physical Damage over time, while increasing Attack Speed and Life Leech. Killing an enemy while this buff is active refreshes the buff duration, and can grant a Frenzy Charge.Per 1% Quality:1Superior2Anomalous3Divergent0.25% increased Attack SpeedBuff grants 0.1% chance to gain a Frenzy Charge when you Hit a Unique EnemyBuff grants 0.02% of Elemental Attack Damage leeched as Life(5-15)% increased Attack Speed
1.2% of Attack Physical Damage Leeched as Life
You take 4% of your Maximum Life per second as Physical Damage
You take 4% of your Maximum Energy Shield per second as Physical Damage
25% chance to gain a Frenzy Charge on Kill
Base duration is (7-10.8) secondsPlace into an item socket of the right colour to gain this skill. Right click to remove from a socket.
while retaining other benefits of the skill as of 2.0.0 with the Blood Rage degeneration damage type changing to physical.
Low life conditions will never trigger while CI is enabled. Effects such as Pain Attunement and On Low Life mods on gear will not activate. For these effects, you must have 50% or less of your current maximum life. Chaos Inoculation sets your maximum life to 1.
Full life conditions will always trigger because you are always at 100% of 1 life.
Interaction with life reduction
Life reductions apply before CI which resets life to 1. For example from Module Error: Item link: No results found for search parameter "Ephemeral Edge"..
Blood magic
When linked with 
Arrogance SupportArrogance SupportAura, Support
Icon: B
Level: (1-20)
Cost & Reservation Multiplier: (220-201)%
Cooldown Time: 0.00 secRequires Level 31Supports any skill with a reservation.Per 1% Quality:1Superior2Anomalous3DivergentSupported Skills have 0.25% increased Aura effectSupported Skills have 0.1% reduced Life ReservationSupported Skills deal 0.5% increased DamageSupported Skills have (10-19)% increased Aura effect
Supported Skills Reserve Life instead of ManaThis is a Support Gem. It does not grant a bonus to your character, but to skills in sockets connected to it. Place into an item socket connected to a socket containing the Active Skill Gem you wish to augment. Right click to remove from a socket.
, affected skills cannot be cast, even if it is an aura which would drain a relative amount of mana/health.
Chaos resistance reduction/penetration
Since CI grants a flat-out immunity to chaos damage, effects that reduce or penetrate chaos resistance (i.e. Occultist's Void Beacon) have no effect against CI.[1]
CI builds
It is generally best to wait until you have high energy shield before taking CI because it's much easier to survive on life at lower levels. Don't be afraid to take life passive skills for survivability while leveling up, since you can remove them later.
Characters with CI are usually more susceptible to stun and status ailments because of their low base life. Rather than taking otherwise useless life nodes as described above, Stun can be mitigated by increasing the Stun Recovery stat with items and passives or unique items such as Module Error: Item link: No results found for search parameter "Eye of Chayula"., Module Error: Item link: No results found for search parameter "Skyforth"., and Module Error: Item link: No results found for search parameter "Valyrium".. Status ailments can be reduced with high elemental resistances, Elementalist's Elemancer perk with at least 3 golems, or unique items such as Module Error: Item link: No results found for search parameter "Auxium". or Module Error: Item link: No results found for search parameter "Dream Fragments"..
Chaos Inoculation works well with some other keystone passives, such as:
- Ghost Reaver converts life gained from life leech into energy shield. Vaal Pact only disables any regeneration granted from passives that's converted by Zealot's Oath as of 3.0.0
- Zealot's Oath applies life regeneration to energy shield. Regen effects that are based on maximum life become based on maximum ES. Note that "regeneration" does not include life flasks, as they are just "Recovery".
Location
Chaos Inoculation is located on the northeast edge of the skill tree.
| Class | Distance from start |
|---|---|
| Witch | 9 |
| Shadow | 11 |
| Scion | 14 |
| Templar | 16 |
| Ranger | 19 |
| Marauder | 23 |
| Duelist | 25 |
Related unique items
| Item | Base Item |  | Stats |
|---|
Version history
| Version | Changes |
|---|---|
| 3.14.1 |
|
| 3.14.0 |
|
| 3.0.0 |
|
| 2.3.2 |
|
| 0.10.0 |
|
| 0.9.10e |
|
| 0.9.7d |
|
| 0.9.6 |
|
| 0.9.5h |
|
| 0.9.5 |
|
| 0.9.4 |
|
References
- ↑ Dan_GGG (February 11, 2016). "Chaos Penetration vs CI?". Official Path of Exile Forums. Retrieved February 11, 2016.
- ↑ Mark_GGG (April 17, 2021). "re: CI (Chaos Inoculation) not granting 100% chaos immunity as it's supposed to with this patch". Official Path of Exile Forums. Retrieved April 20, 2021.