Progenesis

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Progenesis
Amethyst Flask
Lasts (4.23-8.78) Seconds
Consumes (28-31) of 65 Charges on use
+35% to Chaos Resistance
Requires Level 60(20-10)% reduced Charges per use
(-35-35)% increased Duration
When Hit during effect, 25% of Life loss from Damage taken occurs over 4 seconds instead
They were bred in a cosmic ocean of raw creation.
Feasting and drinking of the milk of the mother,
they fought to the death for every last drop.
Right click to drink. Can only hold charges while in belt. Refills as you kill monsters.
Acquisition
Drop restricted
Drops from Uber Maven.
Vendor Offer
4x Alchemy Shard
1x Alteration Shard
Metadata
Item class: Utility Flask
Progenesis
Flask Effect

Progenesis is a unique Amethyst FlaskAmethyst FlaskLasts 6.50 Seconds
Consumes 35 of 65 Charges on use
+35% to Chaos Resistance
Requires Level 18Right click to drink. Can only hold charges while in belt. Refills as you kill monsters.
.

Modifiers

When Hit during effect, 25% of Life loss from Damage taken occurs over 4 seconds instead: This modifier functions similarly to and is multiplicative with Petrified BloodPetrified BloodSpell
Level: (1-20)
Reservation: 35% Mana
Cooldown Time: 1.00 sec
Can Store 1 Use(s)
Cast Time: Instant
Requires Level 24Applies a buff that protects the lower half of your life, preventing some of the immediate life loss when damaged by hits and applying the loss over time instead. Your life cannot be raised above low life other than by flasks, and while above low life, skills will cost life as well as mana.Life Recovery other than Flasks cannot Recover Life to above Low Life
When taking Damage from Hits, 40% of Life loss below half Life is Prevented, then (100-81)% of Life loss prevented this way is lost over 4 seconds
Skills gain a Base Life Cost equal to 40% of Base Mana Cost while not on Low Life

Additional Effects From 1-20% Quality:
-(0.25-5)% of Life loss prevented is lost over 4 seconds
Place into an item socket of the right colour to gain this skill. Right click to remove from a socket.
([1], with Progenesis' effect working first), causing life loss over 4 seconds. Note that this is not considered damage over time. An equal amount of recoup can offset this damage, effectively functioning as damage reduction against hits.

This modifier value scales with flask effect.[2] 300% flask effect will cause all damage from hits to be taken as life loss over time; with 100% recoup or the equivalent after factoring life recovery rate, this provides effective immunity against hit damage.

Item acquisition

Progenesis has restrictions on where or how it can drop. It cannot be chanced.

Drops from Uber Maven.

Ruthless mode

Utility Flasks cannot gain charges while active in Ruthless mode. This flask also has a flask duration of (2.92-6.07) seconds instead.

Design attribution

Progenesis was created in a collaboration with Ben as a reward for taking a prize place in the 3.18 boss kill event.[3]

Version history

Version Changes
3.20.0
  • Introduced to the game.

References

  1. Ben_ (Dec, 2022). "pb flask". Twitch. Retrieved April 11, 2023.
  2. sergeantminor (Dec 16, 2022). "Progenesis Mechanics and Interactions". YouTube. Retrieved April 11, 2023.
  3. Community_Team (May 23, 2022). "Sentinel Boss Kill Event Announcement". Official Path of Exile Forums. Retrieved August 8, 2022.